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KDEL is a target peptide sequence in the amino acid structure of a protein which prevents the protein from being secreted from the endoplasmic reticulum (ER). A protein with a functional KDEL motif will be retrieved from the Golgi apparatus by retrograde transport to the ER lumen. It also targets proteins from other locations (such as the cytoplasm) to the ER. Proteins can only leave the ER after this sequence has been cleaved off. The abbreviation KDEL is formed by the corresponding letters to each amino acid. This letter system was defined by the IUPAC and IUBMB in 1983, and is as follows: *K—Lysine *D—Aspartic acid *E—Glutamic acid *L—Leucine Therefore, the sequence in three letter code is: Lys-Asp-Glu-Leu. ==See also== * ER retention * KKXX (amino acid sequence) * Endoplasmic reticulum protein retention receptors * *KDELR1 * *KDELR2 * *KDELR3 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「KDEL (amino acid sequence)」の詳細全文を読む スポンサード リンク
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